Order Allopurinol (Allopurinol) online in the USA from a licensed pharmacy

Product Name	Allopurinol
Dosage	100 mg, 300 mg
Active Ingredient	Allopurinol
Form	Oral Tablets
Description	Xanthine oxidase inhibitor used to manage gout and chronic hyperuricemia, prevent uric acid kidney stones, and reduce tumor lysis syndrome risk during cancer therapy.
How to Order Without Prescription	Prescription required in the USA. Order through a licensed pharmacy using a valid Rx from your healthcare provider or telehealth.

Allopurinol is a well-established prescription medication used throughout the United States to lower uric acid levels in the blood. As a xanthine oxidase inhibitor, it helps prevent gout flares, promotes tophus reduction over time, lowers the risk of uric acid kidney stones, and is commonly used to reduce the risk of tumor lysis syndrome in certain patients undergoing chemotherapy. In U.S. pharmacies, allopurinol is available as oral tablets, most commonly at strengths of 100 mg and 300 mg, with dosing individualized and titrated based on serum urate goals and kidney function.

Allopurinol has been used for decades and remains a first-line urate-lowering therapy recommended by professional societies such as the American College of Rheumatology (ACR). In the United States, it is a prescription-only therapy. If you believe allopurinol may be right for you, speak with your clinician or connect via telehealth for evaluation, diagnosis, and a prescription when appropriate. Once prescribed, U.S.-licensed pharmacies can dispense the medication and arrange home delivery, depending on state and pharmacy policies.

Allopurinol cost and availability in the USA

Generic allopurinol offers a cost-effective option for long-term urate-lowering therapy. Prices vary by pharmacy, insurance coverage, and location. In many U.S. retail and mail-order pharmacies, a month’s supply of 100 mg or 300 mg tablets is typically affordable, and discount programs or coupons may further reduce out-of-pocket costs. Brand-name options may be available in limited settings, but generic allopurinol is the most commonly dispensed version.

The total cost for you will depend on your prescribed dose and the number of tablets required per day. Because allopurinol is usually started at a low dose and gradually increased to reach target serum urate levels, your monthly tablet count may change during titration. Your pharmacist can help optimize supply quantities for convenience and value once your stable dose is established.

Always use a prescription from a licensed U.S. healthcare provider. Reputable U.S. pharmacies and health plans offer transparent pricing, adherence support, and counseling to promote safe and effective use. If you are uninsured, ask the pharmacy about savings options.

Where can I get allopurinol in the United States?

If your clinician recommends allopurinol, you can fill your prescription at local chain drugstores, independent pharmacies, or through mail-order services associated with your insurance plan. Many telehealth providers also coordinate electronic prescriptions directly to the pharmacy of your choice. If you require ongoing refills, automatic refill programs and 90-day supplies may be available to improve adherence and reduce copays.

As a U.S. prescription medicine, allopurinol should only be obtained from licensed pharmacies. This ensures medication authenticity, proper storage, and access to pharmacist counseling. If you have questions about availability, dosing, or interactions, your pharmacist and healthcare provider can guide you.

Online ordering and home delivery options vary by state and pharmacy. Most major pharmacies now provide secure online portals for refills, shipment tracking, and reminders, making it convenient to maintain your therapy as prescribed.

Allopurinol access: steps to start treatment

Getting started typically involves: evaluation by a clinician, diagnosis of gout or hyperuricemia-related condition, a discussion of lifestyle measures (diet, hydration, alcohol moderation), selection of a urate-lowering therapy (often allopurinol), and a plan for anti-inflammatory prophylaxis to reduce early flare risk. After an electronic prescription is sent to your preferred U.S. pharmacy, you can pick up your medication in person or request mail delivery where available.

What is allopurinol?

Allopurinol is a xanthine oxidase inhibitor that reduces the production of uric acid. By decreasing serum urate, it helps prevent gout flares and complications, promotes gradual dissolution of existing urate crystals (tophi), and lowers the risk of uric acid stone formation. It also supports prevention of tumor lysis syndrome in certain oncology settings by limiting uric acid accumulation during rapid cell breakdown.

Unlike pain relievers, allopurinol does not treat acute pain directly. Instead, it provides long-term control by lowering uric acid to a target level, typically below 6 mg/dL for most people (or below 5 mg/dL in those with tophi), thereby reducing both the frequency and severity of gout flares over time.

Allopurinol is taken daily and is generally well tolerated when started at a low dose and titrated gradually. Clinical monitoring and patient education are essential components of successful long-term management.

How allopurinol works

Allopurinol and its active metabolite, oxypurinol, competitively inhibit xanthine oxidase—the enzyme responsible for converting hypoxanthine and xanthine to uric acid. Inhibiting this pathway lowers circulating uric acid, decreases crystal deposition in joints and tissues, and reduces the conditions that precipitate gout attacks and uric acid stone formation.

Because lowering urate can transiently mobilize existing crystals, patients may experience flares during early treatment. This is why guidelines recommend anti-inflammatory prophylaxis (such as colchicine, NSAIDs, or low-dose corticosteroids) when initiating or escalating allopurinol. Over time, sustained urate reduction leads to fewer flares and improved joint health.

Indications: when clinicians prescribe allopurinol

Common U.S. indications include:

• Chronic gout with hyperuricemia, including those with frequent flares or tophi
• Asymptomatic hyperuricemia in select patients with complications or very high urate levels at clinician discretion
• Prevention of recurrent uric acid nephrolithiasis (kidney stones)
• Prevention of tumor lysis syndrome–related hyperuricemia in oncology settings

Your healthcare provider will determine whether allopurinol is appropriate for your specific situation and will adjust therapy based on your response, medical history, and any comorbid conditions.

Allopurinol dosing and titration (adults)

Dosing is individualized. The general approach in the USA is “start low and go slow,” with a treat-to-target strategy:

• Starting dose: often 100 mg once daily (or 50 mg daily in advanced chronic kidney disease).
• Titration: increase by 50–100 mg every 2–5 weeks, guided by serum urate levels, kidney function, and tolerability.
• Maintenance dose: the dose required to maintain serum urate below the target (commonly <6 mg/dL, or <5 mg/dL for tophaceous gout). Many patients require 300 mg/day or higher; some may need divided doses at higher totals.
• Maximum dose: up to 800 mg/day in divided doses in the U.S., if clinically indicated and tolerated, with close monitoring.

To reduce early flare risk, clinicians often prescribe prophylaxis (e.g., colchicine 0.6 mg once or twice daily, an NSAID, or low-dose corticosteroids) for at least the first 3–6 months and for at least 3 months after achieving serum urate target, per guideline-based care.

Renal dosing considerations

Kidney function affects oxypurinol clearance. In CKD, clinicians may start at a lower dose (e.g., 50 mg daily) and titrate more slowly, with careful monitoring for efficacy and tolerability. Contemporary evidence supports treat-to-target dosing in CKD, guided by urate levels and safety monitoring, rather than a strict fixed-dose cap based solely on eGFR.

Pediatric considerations (specialist-guided)

Allopurinol may be used in pediatric patients under specialist care, particularly for tumor lysis syndrome prevention. Dosing is weight-based (often divided doses), and safety monitoring is essential. Pediatric use should be managed by clinicians experienced in pediatric oncology or nephrology, as appropriate.

Starting allopurinol during a gout flare

Historically, initiation was delayed until after a flare resolved. Current practice often supports continuing or even initiating urate-lowering therapy during a flare if anti-inflammatory therapy is also provided, as interrupting or delaying urate control may not be necessary. Decisions should be individualized; discuss timing with your healthcare provider.

Allopurinol for kidney stones and tumor lysis syndrome

For recurrent uric acid kidney stones, allopurinol can reduce uric acid production, while hydration and urine alkalinization (e.g., potassium citrate) help prevent stone formation. Your clinician may order periodic urine studies to guide therapy.

In oncology, allopurinol can be used to reduce the risk of uric acid elevation associated with tumor lysis syndrome. It is typically started prior to chemotherapy and continued during the risk period, in coordination with other preventive strategies (e.g., hydration; alternative agents like rasburicase in select cases). Dosing and duration are determined by the oncology team.

Safety profile and side effects

Allopurinol is generally well tolerated. Common side effects may include:

• Mild skin rash or itching
• Gastrointestinal upset: nausea, diarrhea, or abdominal discomfort
• Headache or drowsiness
• Elevations in liver enzymes (usually mild and reversible)

Serious but uncommon reactions can occur, including allopurinol hypersensitivity syndrome (AHS), a severe, potentially life-threatening hypersensitivity reaction often associated with rash, fever, facial swelling, mucosal involvement, hepatitis, eosinophilia, and kidney dysfunction. Seek urgent medical care if you develop rash (especially with blisters or peeling), fever, mouth sores, facial swelling, difficulty breathing, yellowing of the skin/eyes, dark urine, severe fatigue, or signs of allergic reaction.

HLA-B*58:01 screening

The HLA-B*58:01 allele significantly increases the risk of AHS. Screening is recommended in certain populations with higher prevalence (e.g., individuals of Southeast Asian descent, including Han Chinese, Korean, Thai; and African American patients), or when clinical risk is elevated. If you test positive, your clinician will typically avoid allopurinol and consider alternatives. Discuss genetic screening with your healthcare provider.

Risk factors for severe rash

Potential risk factors include recent initiation (first few months), higher starting doses without gradual titration, concurrent thiazide diuretics, kidney impairment, and the presence of HLA-B*58:01. Always report new skin findings immediately to your clinician.

Drug interactions

Some medicines interact with allopurinol. Provide your healthcare team with a complete list of prescription drugs, OTC products, vitamins, and supplements. Notable interactions include:

• Azathioprine and 6-mercaptopurine: reduce dose substantially (often to 25–33% of usual) due to increased exposure; close monitoring is essential.
• Warfarin: potential enhancement of anticoagulant effect; INR monitoring may be needed.
• Thiazide diuretics: may increase risk of hypersensitivity reactions; monitor closely.
• Ampicillin/amoxicillin: increased likelihood of rash; consider alternatives if feasible.
• Didanosine: coadministration may increase didanosine levels; avoid or monitor if necessary.

This is not a complete list. Your pharmacist and clinician will help manage interactions, adjust doses, or select alternative therapies as needed.

How to take allopurinol

Take allopurinol exactly as prescribed. Many patients take it once daily; higher total daily doses may be divided to improve tolerability. It can be taken after meals to reduce stomach upset. Maintain adequate hydration, unless your clinician advises otherwise.

Allopurinol is part of a long-term strategy. Do not stop the medication during a flare unless your clinician instructs you to do so. Consistent daily dosing is key to reaching and maintaining your serum urate target.

Monitoring and follow-up

Monitoring typically includes periodic serum urate checks during titration (every 2–5 weeks) and less frequently once at goal. Your clinician may also monitor kidney function, liver enzymes, blood counts, and assess gout symptoms, tophi status, and medication adherence. Keep all scheduled appointments and lab tests so your dose can be optimized safely.

Lifestyle measures that support gout control

Medication works best alongside lifestyle strategies:

• Hydration: aim for adequate fluid intake to help reduce stone risk and support uric acid excretion.
• Diet: limit purine-rich foods (e.g., organ meats, certain seafood), moderate high-fructose corn syrup and alcohol (especially beer and spirits), and emphasize vegetables, fruits, low-fat dairy, whole grains, and lean proteins.
• Weight management: gradual weight loss if overweight can reduce flare frequency.
• Comorbidity management: control blood pressure, lipids, and glucose; review diuretic use with your clinician if flares are frequent.

Work with a registered dietitian or your healthcare provider to tailor a plan that fits your health needs and preferences.

Pregnancy, breastfeeding, and special populations

Allopurinol use during pregnancy should be individualized; clinicians weigh potential benefits and risks. If you become pregnant or plan to conceive, notify your healthcare provider promptly to discuss options. For breastfeeding, limited data are available—your clinician will help you evaluate the risks and benefits and consider alternatives as needed.

In older adults or those with multiple comorbidities, dose titration and monitoring may need closer attention. Patients with CKD can still benefit from allopurinol, with appropriate dosing and careful follow-up.

Common questions about allopurinol

Is allopurinol a painkiller? No. It lowers uric acid over time to prevent flares but does not provide immediate pain relief. Use anti-inflammatory medicines for acute attacks as directed by your clinician.

How long before it starts working? Serum urate can start to decline within days, but clinical benefits (fewer flares, tophus reduction) develop over weeks to months as levels remain at target.

Will I still get flares after starting? Possibly, especially early on. Prophylaxis (e.g., colchicine or NSAIDs) helps. Do not stop allopurinol during a flare unless your clinician instructs you to.

What is the target serum urate? Generally below 6 mg/dL, or below 5 mg/dL with tophi, per guideline-based care.

Can I drink alcohol? Moderate or limit alcohol, particularly beer and spirits, which can raise uric acid and trigger flares. Discuss safe intake with your clinician.

What if I miss a dose? Take it when you remember unless it’s close to your next dose. Do not double up. Consistency helps keep uric acid at goal.

Dietary guidance to complement allopurinol

Diet alone is often insufficient to control gout, but it can support medical therapy. Consider the following:

• Favor plant-forward meals, low-fat dairy, and lean proteins (e.g., poultry, tofu).
• Limit organ meats, certain fish (anchovies, sardines), and large portions of red meat.
• Reduce sugar-sweetened beverages and foods high in high-fructose corn syrup.
• Choose water or unsweetened beverages; coffee (without high-sugar additives) may be acceptable for many.
• Maintain a consistent eating pattern to support weight and metabolic health.

As always, personalize nutrition with your healthcare team, especially if you have diabetes, kidney disease, or other conditions requiring specific dietary adjustments.

Adherence tips from our pharmacists

To keep your uric acid at target:

• Take allopurinol at the same time every day.
• Use smartphone reminders or pill organizers.
• Schedule periodic lab tests and follow-up appointments.
• Request 90-day supplies if eligible to reduce trips and copays.
• Ask your pharmacist about synchronization of refills for all your medications.

If cost or side effects are barriers, talk to your healthcare provider promptly. Lower-cost generic options, dose adjustments, or supportive therapies may help.

Recognizing and managing side effects

Most side effects are mild and transient. If you experience a rash, stop taking allopurinol and seek medical attention right away. For GI upset, taking the dose after meals may improve tolerability. If you notice dark urine, yellowing of the skin or eyes, persistent fatigue, or unusual bleeding or bruising, contact your clinician.

Report all side effects, even those not listed here, to your healthcare team. You can also report adverse events to the FDA via MedWatch.

Co-therapies: colchicine, NSAIDs, and corticosteroids

Because urate-lowering can trigger flares early on, anti-inflammatory prophylaxis is commonly prescribed for at least 3–6 months when initiating or escalating allopurinol. Colchicine is often preferred for prophylaxis in the absence of contraindications, but NSAIDs or low-dose corticosteroids may be used. Your clinician will help tailor the plan to your health profile.

Do not stop allopurinol during flares

Continue your daily allopurinol through an acute flare unless your clinician advises otherwise. Managing the flare with anti-inflammatories while maintaining urate-lowering therapy supports long-term control.

Storage and handling

Store allopurinol tablets at room temperature away from moisture and heat. Keep out of reach of children and pets. Do not use if the packaging is damaged or past the expiration date. If you have unused tablets, ask your pharmacy about safe medication disposal or take-back programs.

Clinical evidence and guideline alignment

Allopurinol is supported by decades of clinical use and guideline recommendations (e.g., ACR). Modern treat-to-target strategies emphasize sustained serum urate control to prevent flares and reduce tophi. In CKD, careful titration with monitoring is recommended rather than underdosing. Pharmacogenetic risk (HLA-B*58:01) is increasingly recognized, informing safe prescribing in high-risk groups.

A note on authenticity and U.S. regulations

In the United States, allopurinol is dispensed by prescription only. To ensure medication quality, always obtain it from U.S.-licensed pharmacies. These pharmacies comply with FDA and state board regulations, handle recalls, offer counseling, and support safe use. Beware of websites offering prescription medications without a valid prescription—such practices may be unsafe and unlawful.

Ready to manage gout long-term? Start the conversation today

If recurrent gout flares or elevated uric acid are affecting your quality of life, speak with your clinician about whether Allopurinol (allopurinol) is appropriate for you. With a valid prescription, you can fill it at a licensed U.S. pharmacy and take advantage of convenient delivery options where available. Our team prioritizes safety, transparency, and expert support.

• Prescription-only in the USA — coordinated through your healthcare provider
• Fast, secure dispensing and delivery options via licensed pharmacies
• Quality-assured medication from trusted manufacturers
• Cost-effective generic options and 90-day supplies where eligible
• Knowledgeable pharmacist support for dosing, interactions, and monitoring

Join many patients nationwide who maintain low uric acid and fewer flares with guideline-based care. Take the next step toward long-term gout control with Allopurinol under your clinician’s guidance.

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